https://www.dibblelab.com/members daily 0.75 2025-04-02 https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/856b3495-fa36-4ee3-a9a7-500c585edf1c/Christian+Dibble+Picture+2025+copy.jpg People - Christian C. Dibble, Ph.D. Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/ffa4d3bb-69f7-4b20-aba2-a519f06a5f85/Sam+Portrait.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/6fd5a820-fce8-4157-bcc2-4bad1b14cde5/Sarah+Portrait.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/46cce9dd-fb7f-4950-926b-46eb0fbba35c/Amelie+Profile+Pic.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/4700374f-3a89-49b4-91b8-2e53a2217bc0/1723589614620.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/ac2386f9-9623-46e7-9e95-93c32e875999/LDC+Head+Shot+1+2025.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/1f6c6ce9-d53d-4071-a12b-5a0b65f3bf43/Amaury+Dassaux+LinkedIn+Pic.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/86db041f-aa07-4389-8540-e4a89072d1cd/Josh_Allen_SEPT2021_%28cropped2%29.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/03192b2d-02c7-443c-8db9-397001dbf8c9/Yoda-Retina_2a7ecc26.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/90202969-682e-432e-915d-efee2d1e03b5/stone-roses-sr001stdo.jpg People https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/3047b766-625b-479f-907e-2d5f96b015da/1024px-Portrait_of_Fritz_Albert_Lipmann_%281899-1986%29%2C_Biochemist_%282551001689%29.jpg People https://www.dibblelab.com/home daily 1.0 2025-03-28 https://www.dibblelab.com/contact-1 daily 0.75 2025-03-28 https://www.dibblelab.com/research daily 0.75 2020-05-27 https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/1590514428862-XDRK6ICOF2SB5ACT7OCN/Screen%2BShot%2B2020-05-26%2Bat%2B11.28.26%2BAM.jpg Research - PI3K Signaling and Coenzyme A Metabolism The goal of the Dibble laboratory is to understand the regulatory relationship between cellular signaling pathways and metabolic pathways. We are particularly interested in the Class I PI3K (phosphoinositide-3-kinase) signaling pathway which is a major regulator of glucose and lipid metabolism and is one of the two most frequently activated signaling pathways in cancer. Production of the lipid second messenger phosphatidylinositol-3,4,5-triphosphate (PIP3) by PI3K at the membrane recruits and activates effector proteins, such as the kinase AKT, to promote nutrient uptake, anabolic metabolism, and growth. Physiological activation of PI3K by secreted ligands such as hormones, cytokines, and growth factors ties cellular metabolism to the systemic metabolic status of the organism. In cancer, PI3K signaling becomes growth factor-independent due to mutations in PI3K itself (PIK3CA is the second most-commonly point-mutated gene in cancer) or in major upstream cancer drivers (e.g. EGFR, MET, KRAS, PTEN). Although the ability of oncogenic PI3K mutants to drive tumorigenesis suggests PI3K directs a comprehensive and integrated metabolic program, the list of control points through which PI3K signaling is known to directly control metabolic activity is surprisingly short. The metabolic cofactor Coenzyme A (CoA) shuttles carbon within the cell (e.g. as acetyl-CoA) and is essential for several core metabolic processes including the TCA cycle, de novo lipid synthesis, and histone acetylation. Our lab has uncovered a novel regulatory connection between PI3K signaling and CoA metabolism and ongoing research in the lab aims to further understand this relationship. Ultimately, the hope is to gain a deeper understanding of the role metabolic pathways play in supporting the PI3K-dependent program that is so intensely selected for in tumors. Dependencies within the signaling-metabolism nexus may be therapeutically exploited in a way that provides a greater therapeutic window compared to the targeting of signaling pathways directly. Pubmed Bibliography https://www.dibblelab.com/about daily 0.75 2025-04-02 https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/1578604847952-M7DYQHTAFM7JZZW20NFX/bidmc_purple_leftjpg.jpg Institutions and Programs - Beth Israel Deaconess Medical Center (BIDMC), Pathology Department and Cancer Center Our lab is a member of the Pathology Department (Experimental Pathology Division) and the Cancer Center of Beth Israel Deaconess Medical Center (BIDMC). BIDMC is located in the Longwood Medical Area of Boston and is one of the four teaching hospitals of Harvard Medical School. BIDMC Department of Pathology Research Website https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/1590504514852-S72HGXH8KZENXMNJ15ZH/HMS+logo.jpg Institutions and Programs - Harvard Medical School Dr. Dibble is an Assistant Professor at Harvard Medical School. The Pathology Departments of BIDMC and the other Harvard teaching hospitals form the Pathology Department of Harvard Medical School. Harvard Medical School https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/1590577914471-M7H4J5V1RYVL5DEPDIIJ/BBSTitle7+copy.png Institutions and Programs - Biological and Biomedical Sciences (BBS) Ph.D. Program at Harvard Medical School Dr. Dibble is a faculty member of the BBS Ph.D. program at Harvard Medical School. BBS Ph.D. Program https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/1590599560269-GW8L3C318C3PR5LITRTZ/TitleDiversity-1.png Institutions and Programs - Summer Honors Undergraduate Research Program (SHURP) at Harvard Our lab participates in SHURP, a ten-week summer research program primarily for college students belonging to groups that are under-represented in the sciences. SHURP https://www.dibblelab.com/photos daily 0.75 2020-05-27 https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/1590588212932-OAMBFQOEYCM21UYZNLPX/Photo+Sep+27%2C+9+35+13+AM+copy.jpg Photos 2019 Dibble, Toker, Manning Lab Joint Retreat, Lake Winnipesaukee, NH https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/88d578e3-53ff-4917-87f7-a0b8cc4d6e9b/Christian+and+Luz+Del+Carmen+in+lab+2025.jpg Photos 2025 Christian and Luz Del Carmen in the lab at Beth Israel Deaconess Medical Center, Boston, MA https://www.dibblelab.com/resources daily 0.75 2020-05-27 https://www.dibblelab.com/funding daily 0.75 2025-03-28 https://images.squarespace-cdn.com/content/v1/5e1763821e1cfa39fe1834a0/63d92f1f-d9fb-4f51-9c21-9021eb92e834/Funding-Featured-Image.png https://www.dibblelab.com/book-a-class daily 0.75 2025-05-12